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In purine biosynthesis, two glutamines are used to generate inosine monophosphate (IMP), a precursor of both adenosine monophosphate (AMP) and guanosine monophosphate (GMP)

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This means that if the model were shown two patients, one who experienced vomiting and one who did not, it would give the patient who experienced vomiting the higher predicted risk about 68% of the time

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Many patients experience both nausea early on and continued steady weight loss throughout treatment